Features

This year’s crop of winning products features many with a clinical focus and others that represent significant advances in sequencing, single-cell analysis, and more.

Scientists studying pathogens such as Chlamydia, Legionella, and Listeria get a master class in how to control the internal workings of mammalian cells.

Aberrant immune activation, the main cause of prematurity and stillbirths, could be preventable through interventions such as maternal vaccination. 

Evidence is mounting that epigenetic marks on DNA can influence future generations in a variety of ways. But how such phenomena might affect large-scale evolutionary processes is hotly debated.

Despite recent advances in the study of eukaryogenesis, much remains unresolved about the origin and evolution of the most complex domain of life.

All multicellular creatures interact with bacteria, but some have taken the relationship to another level with highly specialized structures that house, feed, and exploit the tiny organisms.

Noncoding RNAs are proving to be critical players in the evolution of brain anatomy and cognitive complexity.

Thirty years out from the start of the Human Genome Project, researchers have finally finished sequencing the full 3 billion bases of a person’s genetic code. But even a complete reference genome has its shortcomings.

Once thought of as a mere motor coordination center, the “little brain” is now appreciated as participating in higher neurological processes.

The normal functions of peptides that aggregate in Alzheimer’s, Parkinson’s, and Huntington’s have been largely overlooked by scientists, but some argue that they are critical for understanding the development of disease.

Today’s extinction rates are sky-high. But scientists debate if that’s sufficient evidence to conclude that Earth is undergoing a mass extinction event—or whether that’s even a helpful designation.

DNA passed to and from all kinds of organisms, even across kingdoms, has helped shape the tree of life, to a large and undisputed degree in microbes and also unexpectedly in multicellular fungi, plants, and animals.

Researchers are turning to the immune system for help in treating addiction and preventing overdose.

Many species of birds and other vertebrates form pair bonds and mate with just one other individual for much of their lives. But the unions don’t always work out. Scientists want to know the underlying factors.

Only recently appreciated as critical components of cellular functions, unstructured stretches of amino acids called SLiMs are key to viral-host interactions.

New techniques have shown that people reached the New World far earlier than the long-standing estimate of 13,000 years ago, but scientists still debate exactly when humans arrived on the continent—and how.

Several lines of evidence suggest that targeting the body’s defense pathways might help treat a subset of people with the psychiatric disorder. But many open questions remain.

The concept of epigenetic inheritance has long been controversial. Some researchers hope that new data on cross-generational effects of environmental exposures will help settle the debate.

A growing appreciation of the bacterial assemblages that live within tumors has researchers striving to understand and capitalize on their role.