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drug development

21 hours ago | 4 min read

A Gene Editing System Corrects Cystic Fibrosis Mutation

An optimized version of prime editing technology raises the possibility of a one-time treatment for cystic fibrosis.
An artist’s representation of the human respiratory system with pink airways on a blue and black background.
A micrograph shows grey sickle-shaped nanovials containing single, fluorescent green mesenchymal stem cells. Some of the cells have secreted high levels of magenta-colored extracellular vesicles.
6 days ago | 4 min read

Tiny Test Tubes Sort Stem Cells for Improved Therapy

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An illustration of a B cell secreting autoantibodies.
Autoimmune Diseases: An Alternative Application for Immunotherapy
The Scientist | Aug 23, 2024 | 1 min read
Learn how immunotherapy is revolutionizing autoimmune disorder treatment.
A 3D rendering of an antibody drug conjugate with attached cytotoxic payloads.
Supporting Antibody-Drug Conjugate Development
The Scientist Staff | Aug 1, 2024 | 2 min read
Industry expertise helps scientists navigate and streamline antibody-drug conjugate research and development.
Colorful wave patterns on a deep purple background.
Bringing the Power of Multiomics Biomarker Discovery into Focus
Sapient Bioanalytics | 1 min read
Take a deep dive into the latest advances for gathering, integrating, and leveraging multiomics data for biomarker discovery.
Dark blue RNA strands with a light blue background.
A CRISPR Tool for Tinkering with the Human Transcriptome
Danielle Gerhard, PhD | Jul 23, 2024 | 5 min read
Human cells repair RNA breaks induced by a programmable CRISPR system, paving the way for temporary treatments for genetic diseases.
mRNA molecule is manufactured from a ribosome. 
A Twisted Secret that Extends mRNA Longevity in Cells
Maggie Chen | Jun 28, 2024 | 3 min read
By tinkering with branched mRNA structures, scientists lay the groundwork to build better vaccines in the future. 
Pharmaceutical manufacturing facility
GMP-Grade Streamlines Cell and Gene Therapy Manufacturing
ACROBiosystems | 1 min read
Standardized quality materials and reagents help scientists improve cell and gene therapy production.
Conceptional image of two pills covered with a circuit-board pattern.
Harnessing the Power of AI to Design Novel Antibiotics
Charlene Lancaster, PhD | Jun 27, 2024 | 4 min read
Generative artificial intelligence allowed researchers to design new, synthesizable antibiotics against a dangerous and often drug-resistant human pathogen.
Fluorescent microscopy image of two adult&nbsp;<em >C. elegans</em> and several offspring.
Automating In Vivo Screens and Challenging Dogma 
Deanna MacNeil, PhD | Jun 19, 2024 | 3 min read
Scientists built a microfluidic lab-on-a-chip device that accelerates compound screens and phenotype analyses in C. elegans models of reproductive aging.
The Future of Disease Modeling for Precision Medicine
The Future of Disease Modeling for Precision Medicine
The Scientist Staff | 1 min read
In this webinar, Elizabeth Proctor will discuss the latest organoid models that scientists use to advance human disease research, with a focus on promoting drug discovery and precision medicine.
Cuboidal DNA origami block containing parallel double helices (gray columns) decorated with tumor antigens (green proteins) and CpG adjuvants (yellow helices) on opposing faces.
Fighting Tumors with DNA Origami
Kamal Nahas, PhD | May 6, 2024 | 5 min read
Researchers bolster antitumor immune defenses using cancer vaccines made from DNA origami.
An abstract illustration of a DNA helix and human lungs.
A New Delivery System Offers Hope for Cystic Fibrosis
Charlene Lancaster, PhD | May 1, 2024 | 4 min read
CRISPR-carrying lipid nanoparticles enabled researchers to correct a rare nonsense mutation in the lungs of a cystic fibrosis mouse model.
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Catch Me If You Can: Sequencing Screens for Rare Disease Genes
The Scientist | 1 min read
As a trailblazer in rare disease research and treatment, Wendy Chung captures the big picture of rare disease genetics with the help of next generation sequencing.
3D rendered RNA strand
MEGA CRISPR: Engineering Better Immunotherapies with RNA Editing
Deanna MacNeil, PhD | Apr 1, 2024 | 3 min read
Multi-targeted Cas13 screens help researchers avoid permanent DNA cuts and evade T cell exhaustion.
A scientist in the middle of the screen is in a lab coat in a laboratory on the left but is dressed in a suit giving a scientific presentation in a board room on the right.
Starting Up a New Endeavor
Shelby Bradford, PhD | Apr 1, 2024 | 2 min read
In his lab, Hashim Al-Hashimi investigated how RNA molecules move. Along the way, he founded a company.
Going with the Flow: An Ultimate Guide to Ultrafiltration
Going with the Flow: An Ultimate Guide to Ultrafiltration
The Scientist Staff | 1 min read
In this webinar, Alli Lynch presents the fundamentals and applications of ultrafiltration in the laboratory setting. 
An illustration of purple-colored single domain antibodies floating in front of a black background.
Single Domain Antibodies: Small but Mighty Therapeutics
The Scientist | Mar 22, 2024 | 1 min read
Discover the benefits of VHH antibody-based therapies.
TK
Infographic: Vaccinating Against Tumors
Shelby Bradford, PhD | Mar 15, 2024 | 1 min read
Cancer vaccines offer the opportunity to use the patient’s own immune system in the fight against tumors.
Boosting the Efficiency of Therapeutic Antibody Development
Boosting the Efficiency of Therapeutic Antibody Development
The Scientist Staff | 1 min read
In this webinar, Daryl Cole will highlight how new technologies improve antibody discovery and production.
A blue background with colorful illustrated viral particles
Delivering Prime Editors With Virus-like Particles
Deanna MacNeil, PhD | Mar 11, 2024 | 3 min read
An iterative engineering approach to improve prime editor delivery helped scientists correct genetic vision defects in mice.
Making Moves Toward Cell Therapy for Diabetes
Deanna MacNeil, PhD | Feb 20, 2024 | 3 min read
A step-by-step cell culture process may improve the quantity and quality of cell replacement therapies.
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