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genetics

21 hours ago | 4 min read

A Gene Editing System Corrects Cystic Fibrosis Mutation

An optimized version of prime editing technology raises the possibility of a one-time treatment for cystic fibrosis.
An artist’s representation of the human respiratory system with pink airways on a blue and black background.
A microscopy image of a mouse embryo expressing the red fluorescent protein mCherry in the central nervous system.
3 days ago | 2 min read

Dynamic Enhancers Orchestrate Development

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A 3D render of multiple RNA strands floating around each other.
Improving RNA Sequencing with FFPE Samples
The Scientist Staff | Sep 2, 2024 | 2 min read
Samples are commonly stored in a way that degrades RNA. Scientists are devising new ways to overcome this obstacle for RNA sequencing. 
3D illustration of a DNA molecule with sparkling effects symbolizing.
A Prime-Editing Based Approach Records Cellular Genetic History
Maggie Chen | Aug 30, 2024 | 3 min read
Researchers developed a technique, ENGRAM, to keep a running log of the elements that control gene expression in cells. 
Optimizing Gene Editing Experimental Design
Optimizing Gene Editing Experimental Design
The Scientist Staff | 1 min read
In this webinar, Jacob Lamberth will discuss the critical variables and strategies for revolutionizing gene editing experiments.
In the foreground, a magnifying glass hovers over a strand of DNA, revealing information hidden in the sequence. Binary code and silhouettes of people are in the background. 
Biotechs Bolster Biosecurity to Safeguard the Future of Nucleic Acid Sequencing
Danielle Gerhard, PhD | Aug 22, 2024 | 10 min read
Synthetic DNA can pose significant biosecurity risks. Experts call for more screening by providers and institutions to mitigate security concerns.
Image of a woolly mammoth skin from the Siberian permafrost.
Rebuilding the Genome of Woolly Mammoths
Laura Tran, PhD | Aug 19, 2024 | 4 min read
A well-preserved 52,000-year-old woolly mammoth skin sample with fossils of ancient chromosomes could offer a glimpse into the history of life.
Optimizing Gene Editing Experimental Design
Optimizing Gene Editing Experimental Design
The Scientist Staff | 1 min read
In this webinar, Jacob Lamberth will discuss the critical variables and strategies for revolutionizing gene editing experiments.
Two cells on a purple background. Two mechanisms of gene silencing are shown in the cell on the left, while a double-strand break in a DNA region is shown in the cell on the right.
What’s the Difference Between Gene Knockdown and Gene Knockout?
Mariella Bodemeier Loayza Careaga, PhD | Aug 15, 2024 | 2 min read
There are many techniques that allow scientists to silence a gene, but whether the effect is transient or permanent depends on the type of approach.
A river surrounded by trees with mountains in the background.
DNA Metabarcoding Reveals Hidden Biodiversity
Hannah Thomasy, PhD | Aug 15, 2024 | 2 min read
Genomicist Mehrdad Hajibabaei empowers Canadian communities to monitor bioindicator species in their local freshwater ecosystems.
Conceptual image of multiomics: Biological samples such as fish and apples are surrounded by scientific instruments like flasks, test tubes, and a microscope, with strands of DNA and different chemical molecules
Multiomics Enables Integrated Biological Analysis 
Rebecca Roberts, PhD | 6 min read
Scientists use multiomics to explore the biological continuum from gene to phenotype, identifying complex molecular mechanisms and pathways.
Conceptual illustration of researchers studying microbes in a petri dish.
Next-Level Screening for Antimicrobial Resistance
The Scientist Staff | Aug 15, 2024 | 2 min read
Bacterial isolate screening improves surveillance, stewardship, and infection control.
Two scientists at a table with two petri dishes of mold. One scientist opens a cloche revealing a meat-like patty made of koji mold.
Mold Burger: Coming Right Up
Laura Tran, PhD | Aug 15, 2024 | 2 min read
From the laboratory to the table, researchers cooked bioengineered fungi into a tempting patty.
An illustration of pink cancer cells attached to a blue surface.
Delving Deeper: Advancing Cancer Research with Molecular Analysis
The Scientist Creative Services Team in collaboration with Thermo Fisher Scientific | 1 min read
The emergence of innovative analytical methods empowers researchers to comprehensively characterize tumor samples.
A sperm and oocyte with a DNA double helix in the background
How Sperm Regulate Offspring Health
Deanna MacNeil, PhD | Aug 9, 2024 | 3 min read
A short term high fat diet before fertilization rewires sperm small RNA expression, passing predisposition to metabolic disease onto offspring.
Artistic rendering of a tumor cell as a misshapen purple blob, surrounded by spiky pink blobs representing NK cells.
Maintaining NK Cells’ Killer Instincts
Aparna Nathan, PhD | Aug 9, 2024 | 4 min read
A protein in natural killer cells keeps them from turning into more docile counterparts.
Twist
Synthetic Screens, Genes, and De Novo Proteins - A Special Podcast Series
The Scientist and Twist Bioscience | 2 min read
In this podcast series, scientists discuss the unique ways they employ synthesized DNA libraries in their research. 
A tilted LED screen showing color-coded DNA sequences.
Expanding the Genetic Alphabet
Kamal Nahas, PhD | Aug 7, 2024 | 5 min read
Synthetic biologists repurposed rarely used codons to install novel amino acids into proteins and expand the capabilities of protein engineering.
The image shows a rendering of a human brain viewed from a lateral perspective with the cerebellum, highlighted in yellow and orange, is situated at the bottom part of the brain where the cerebrum connects with the brainstem. 
Revealing the Mutation Behind a Rare Neurological Disease
Claudia Lopez-Lloreda, PhD | Aug 2, 2024 | 3 min read
After 20 years, scientists studying patients with cerebellar degeneration discovered a mutation that disrupts autophagy.
iStock
Catch Me If You Can: Sequencing Screens for Rare Disease Genes
The Scientist | 1 min read
As a trailblazer in rare disease research and treatment, Wendy Chung captures the big picture of rare disease genetics with the help of next generation sequencing.
An illustration of circulating tumor cells surrounded by red blood cells.
Monitoring Multiple Myeloma Progression through Sequencing
Charlene Lancaster, PhD | Aug 2, 2024 | 4 min read
Irene Ghobrial sequences circulating tumor cells in blood samples to genomically profile patients with multiple myeloma.
The image shows a dorsal view of a whole mount embryonic chick mandible (lower jaw).
Unveiling the Secrets of Head and Face Formation  
Mariella Bodemeier Loayza Careaga, PhD | Aug 1, 2024 | 5 min read
Samantha Brugmann illuminates the cellular and molecular factors that contribute to the formation of craniofacial structures. 
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