tumor immunology

Immune cells form different communities throughout a tumor, potentially disrupting how cancers respond to treatments.

A trio of papers shows that specialized antibodies can direct T cells to destroy cells that display portions of mutant cancer-related proteins, as well as T cells that have become cancerous themselves.

Better understanding the CD8+ T cells already present in tumors could be key to making immunotherapies work for more patients.

A proof-of-concept study uses a strategy similar to the way tumors evade immune detection. The new limbs survive for more than 200 days.

Holding laboratory mice at temperatures lower than those the animals prefer could be altering their physiology and skewing experimental results.