transgenic mice

Standing at the cornerstone of genetic research, Cre-loxP recombination serves as molecular scissors for precisely manipulating the genome.

The Cre-lox recombination method orchestrates remarkable genetic manipulations that remain a gold standard for transgenic mice.

In FIRE mice, the lack of microglia causes myelin overgrowth and eventual degeneration, indicating that microglia may contribute to age-related neurodegenerative diseases.

Mintz’s experiments over her six-decade career were foundational to cancer and genetics research.

A high-salt diet suppressed the growth of tumors in a mouse model of melanoma, apparently because of an interplay between the gut microbiome and natural killer cells.

The University of Alabama at Birmingham neuroscientist aims to determine which cells are most important in prompting the disease’s initiation and progression.

Increasing the expression of two genes from non-Y chromosomes restores spermatogenesis in male mice that lack Y chromosomes.

A transgenic mouse company is paying researchers who mention its animal models in scientific papers.

Some genetically engineered mice harbor unwanted mutations that hitchhike alongside desired modifications, affecting experimental outcomes.

Researchers develop mouse lines to help them see whether the maternal or paternal X chromosome is inactivated.

In a proof-of-principle study, genetic deletion of two genes renders male mice infertile by preventing sperm transport through the vas deferens.

Reprogramming cells within live mice yields a new type of induced pluripotent stem cell.

Scientists make mice strains with multiple mutations in less than a month without using embryonic stem cells.

May 2013's selection of notable quotes

This dramatic science fiction film follows a grieving father using his research to understand his infant son’s gruesome death—and explores the culture and ethics of science along the way.

Fluorescent calcium sensors in transgenic mice give a real-time readout of neuronal activity.

The research community is pulling together to support scientists at the hurricane-damaged NYU, but the facility has also come under fire for its lack of preparedness.

Scientists use molecular techniques to reawaken memories in mice.