Overcoming Roadblocks in PROTAC Characterizations
Overcoming Roadblocks in PROTAC Characterizations
Researchers require an accurate and high throughput method to evaluate proteolysis targeting chimera (PROTAC) interactions.
Researchers require an accurate and high throughput method to evaluate proteolysis targeting chimera (PROTAC) interactions.
protein interactions
A Quick and Efficient Strategy for Affinity Screening
NanoTemper Technologies | Dec 7, 2023 | 1 min read
Researchers assessed the binding affinities of PROTAC binary and ternary complexes with Spectral Shift technology.
A Solution for Measuring In-Solution Interactions
NanoTemper Technologies | Dec 5, 2023 | 1 min read
Scientists used Spectral Shift assays to assess binding affinity and degradation of the oncogene regulator WDR5.
Infographic: Phage Display Allows Rapid Screening of Millions of Peptides
Shelby Bradford, PhD | Dec 4, 2023 | 3 min read
A viral protein expression method links proteins and their coding instructions, enabling easier target identification for downstream analysis.
Visualizing Molecular Interactions without Labels
Cytiva | Aug 17, 2023 | 1 min read
Researchers use label-free surface plasmon resonance to measure affinity and binding kinetics in real time.
Simplifying the Search for Drug Targets
Aparna Nathan, PhD | Aug 1, 2023 | 3 min read
A new machine learning model promises fast prediction of drug-target interactions.
Ankur Jain Explores RNA Aggregations in Neurodegenerative Disease
Hannah Thomasy, PhD | Oct 3, 2022 | 3 min read
The MIT biologist studies how RNA molecules self-assemble and the role these accumulations may play in diseases such as ALS and Huntington’s.
A Complete Guide to Label-Free Binding Analysis
Sartorius | Jul 27, 2022 | 1 min read
Discover how to select the most suitable platform to study biomolecule interactions depending on application and workflow needs.
Infographic: Short Protein Motifs’ Role in SARS-CoV-2 Infection
Conchita Fraguas Bringas and Jakob Nilsson | May 16, 2022 | 4 min read
Known as SLiMs, these stretches of up to 10 amino acids play notable roles in cell biology, including responses to viral invasion.
Viruses Target Super-Short Protein Motifs to Disrupt Host Biology
Conchita Fraguas Bringas and Jakob Nilsson | May 16, 2022 | 10+ min read
Only recently appreciated as critical components of cellular functions, unstructured stretches of amino acids called SLiMs are key to viral-host interactions.
Stress-Induced Molecular Globs Boost Bacterial Fitness
Ruth Williams | Oct 21, 2021 | 4 min read
Liquid conglomerations of molecules that form in bacterial cells in response to stress promote the cells’ survival, a study finds.
Understanding the Complexity of Cancer with Cryo-EM
The Scientist and Thermo Fisher Scientific | Oct 12, 2021 | 1 min read
Explore how researchers use cryogenic electron microscopy (cryo-EM) to identify how mutations affect protein signaling and function through structural or conformational changes.
Technique Talk: Analyzing Molecular Interactions During Monoclonal Antibody Development
The Scientist Creative Services Team in collaboration with Sartorius Corporation | Mar 9, 2021 | 1 min read
In this workshop, you will learn how to measure protein interactions using Octet bio-layer interferometry.
Advancing Disease Research with Mass Spectrometry
The Scientist | Sep 15, 2020 | 1 min read
Explore just how indispensible mass spectrometry is becoming to life science researchers.
The Dark Matter of the Human Proteome
Annie Rathore | Apr 1, 2019 | 10 min read
Advances in the functional characterization of newly discovered microproteins hint at diverse roles in health and disease.
Mass Spec Analysis of Protein Interactions
Jeffrey M. Perkel | Oct 1, 2016 | 7 min read
Using the technique to study how RNA, DNA, lipids, and small molecules interact with proteins