A Bird’s Eye View of the Tumor Microenvironment
A Bird’s Eye View of the Tumor Microenvironment
Immune cells form different communities throughout a tumor, potentially disrupting how cancers respond to treatments.
Immune cells form different communities throughout a tumor, potentially disrupting how cancers respond to treatments.
neutrophils
The Nucleus’ Secret to Shapeshifting
Kamal Nahas, PhD | May 31, 2024 | 4 min read
Neutrophils contort their nuclei into various shapes by moderating one key regulatory protein previously shown to orchestrate DNA organization.
Cell Surface RNA Helps Neutrophils Get Around
Holly Barker, PhD | Apr 2, 2024 | 4 min read
A new study confirms reports of membrane-bound RNA molecules and points to their role in neutrophil migration.
Characterizing Cancer via the Immune Response
The Scientist | 1 min read
Researchers explore the immune system to further understand cancer and illuminate therapy development.
A Genetic Predisposition to Vitamin D Deficiency Contributes to Severe COVID-19
Iris Kulbatski, PhD | Jun 1, 2023 | 3 min read
Ana Teresa Freitas discussed how individual variation in vitamin D synthesis and metabolism influences susceptibility to upper respiratory viruses.
Mucus-Eating Gut Bacteria May Promote Fever After Cancer Treatment
Alejandra Manjarrez, PhD | Jan 5, 2023 | 3 min read
The expansion of mucus-degraders in the mouse gut—possibly due to poor nutrition—thins the colon’s mucus layer and may weaken defenses against blood-infecting microbes.
How Migrating Cells Navigate Biological Mazes
Laura Mac-Daniel, PhD | 4 min read
A key protein that detects changes in plasma membrane curvature guides immune-like cells through environmental obstacles.
Genetic Predisposition to Vitamin D Deficiency Contributes to Severe COVID-19
Iris Kulbatski, PhD | Aug 15, 2022 | 3 min read
Ana Teresa Freitas discusses how individual variation in vitamin D synthesis and metabolism influences susceptibility to upper respiratory viruses.
Psychological Stress Distracts the Immune System from Fighting Infections
Jennifer Zieba, PhD | Aug 8, 2022 | 3 min read
Acute stress makes immune cells migrate immediately to the bone marrow, which prepares the body for injury at the expense of increasing infectious disease susceptibility.
Checking Checkpoints for Treating Cancer
The Scientist | 1 min read
Researchers devise strategies to improve checkpoint inhibitor therapy and predict patient response.
Early Inflammation Protects Against Chronic Pain, Study Finds
Alejandra Manjarrez, PhD | May 12, 2022 | 3 min read
Human data and experiments in mice challenge the common use of anti-inflammatory drugs to treat pain.
Smallpox Vaccine Recruits Skin Bacteria to Fight Disease
Patience Asanga | Apr 26, 2022 | 3 min read
A mouse study points to a possible mechanism by which the smallpox vaccine helped eradicate the disease in the 1980s.
Janus-Faced Neutrophils
Sophie Fessl, PhD | Mar 2, 2022 | 4 min read
The immune cells facilitate healing, but they may also help tumors metastasize to the lungs after injury, a study in mice finds.
Microscopic Robots Deliver Drugs to the Brain
Asher Jones | Mar 30, 2021 | 5 min read
Researchers turned white blood cells called neutrophils into drug-smuggling “neutrobots,” which penetrated the blood-brain barrier to treat brain cancer in mice.
The Immune Hallmarks of Severe COVID-19
Katarina Zimmer | Sep 16, 2020 | 10+ min read
Researchers are trying to make sense of immune systems gone haywire and develop biomarkers to predict who will become the sickest from a coronavirus infection.
Blood Replacement Rescues Mice from Stroke Damage
Amanda Heidt | Aug 31, 2020 | 5 min read
When mice that had suffered a stroke were given blood from a healthy donor, they experienced less tissue and neurological damage.
Neutrophil Extracellular Traps May Augur Severe COVID-19
Alakananda Dasgupta | May 28, 2020 | 6 min read
These webs of chromatin and proteins, released by immune cells to control microbial infections, could serve as a therapeutic target in coronavirus infections.
Infographic: How NETs Work
Borko Amulic and Gabriel Sollberger | Oct 1, 2019 | 3 min read
While neutrophil extracellular traps help guard the body from infection, they also can contribute to a range of diseases.
Why Immune Cells Extrude Webs of DNA and Protein
Borko Amulic and Gabriel Sollberger | Oct 1, 2019 | 10 min read
Extracellular webs expelled by neutrophils trap invading pathogens, but these newly discovered structures also have ties to autoimmunity and cancer.
Image of the Day: White Blood Cell Webs
Emily Makowski | Sep 5, 2019 | 1 min read
Neutrophil extracellular traps may hold clues to the cause of skin lesions in patients with a painful condition called hidradenitis suppurativa.