mutation

Epigenetic control of gene expression can switch on genes that push cell division into overdrive independently of genetic faults.

Some species of lizards, grasshoppers, and crustaceans have adopted a ladies-only lifestyle.

Although epigenetic changes were long thought to largely act on the genome, rather than as part of it, research is now showing that these patterns can, directly or indirectly, change the genetic code.

Evidence is mounting that epigenetic marks on DNA can influence future generations in a variety of ways. But how such phenomena might affect large-scale evolutionary processes is hotly debated.

Most differences in gene expression among cells within a tumor are likely due to environment or noise, a study suggests. 

A new study points to repercussions of the Medieval pandemic for the health of modern humans.

The black fur allele has fitness costs but also confers higher immunity against canine distemper virus, making mix-and-match mating key to population survival.

The National Institute of Allergy and Infectious Diseases was not aware that the work involved a chimeric strain of SARS-CoV-2, STAT reports.

Researchers made the find using an algorithm that purportedly distinguishes between mutations that were selected for and those that came along for the ride by coincidence, a feat that has long eluded scientists.

A single amino acid substitution in a protein causes increased neuron production in the frontal lobes of humans compared to Neanderthals—a tiny difference that could have given our species a cognitive edge, researchers say.

Most animals can’t pass on mutations that arise spontaneously throughout their lives—but Elkhorn corals can.

A new genetic sensor called PRISM makes use of a host cell’s DNA replication machinery to trigger fluorescence in neurons with damaged DNA.

A new tool called PRISM draws on virus-host interactions and a DNA repair pathway to help researchers visualize how cellular stress may contribute to neurodegenerative disease.

Most of the human induced pluripotent stem cells stored at major cell line repositories and used in research harbor thousands of DNA errors, a study finds, highlighting the need for improved quality control measures.

Research traces the evolution of a gene variant that reduces the risk of Alzheimer’s disease, finding that it originally evolved in response to infectious bacteria.

Tumors contain thousands of genetic changes, but only a few are actually cancer-causing. A quicker way to identify these driver mutations could lead to more targeted cancer treatments.