mTOR

Exercise changes our muscles, but its molecular effects depend on the type of exercise. 

Researchers found new mechanisms and drug targets for cystinosis.

Biogerontologist Matt Kaeberlein studies aging pets to determine how to improve healthspan in dogs and their humans.

The MIT biologist studies how RNA molecules self-assemble and the role these accumulations may play in diseases such as ALS and Huntington’s.

Hundreds of the school’s faculty, students, and trainees are protesting its consideration of David Sabatini, who left his previous posts after alleged sexual misconduct.

The researcher, known for his work on the mTOR signaling pathway, is no longer with MIT’s Whitehead Institute or HHMI following an investigation into his conduct.

Despite the treatment being given for only six weeks, the positive effects lasted for a year.

At low doses, resveratrol enhanced human T-cell activity in vitro, while at high doses it interfered with cell signaling. 

Douglas Lowy and John Schiller, whose work led to the HPV vaccine, and Michael Hall, who discovered the TOR pathway, win this year’s prizes.

Food restriction decreases a metabolite that impedes associative learning in worms. 

Studies of infected rhesus monkeys reveal the virus’s long-term hiding places in the body.

Even when a clinical trial fails, some patients improve. What can researchers learn from these exceptional responders?

Associate Professor, Department of Neuroscience, Baylor College of Medicine. Age: 39

Fixing impaired pruning and autophagy signaling in neurons eases the symptoms of autism in a mouse model of the disorder.

Reducing the levels of mTOR in rodents extends their lifespan by about 20 percent, though not without consequences.

Targeting a molecular pathway involved with learning and memory helps rats with a taste for booze wean themselves off of the sauce.

Principal Investigator, Whitehead Institute for Biomedical Research. Associate Professor, Department of Biology, Massachusetts Institute of Technology. Age: 44