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mRNA molecule is manufactured from a ribosome.
A Twisted Secret that Extends mRNA Longevity in Cells
By tinkering with branched mRNA structures, scientists lay the groundwork to build better vaccines in the future. 
A Twisted Secret that Extends mRNA Longevity in Cells
A Twisted Secret that Extends mRNA Longevity in Cells

By tinkering with branched mRNA structures, scientists lay the groundwork to build better vaccines in the future. 

By tinkering with branched mRNA structures, scientists lay the groundwork to build better vaccines in the future. 

mRNA

Headshots of three people smiling and looking at camera.
2023 Brain Prize Awarded for Research on Synaptic Plasticity
Natalia Mesa, PhD | Mar 23, 2023 | 3 min read
The Lundbeck Foundation announces an international cohort of neuroscientists have collectively won the €1.3 million Brain Prize.
Michael Green smiling at the camera in front of a shelf in the lab
Molecular Biologist Michael Green Dies at 69
Lisa Winter | Mar 7, 2023 | 2 min read
Beyond his achievements in academia, he also cofounded three pharmaceutical companies and filed 15 patents related to cancer therapeutics. 
Accelerating Antibody Discovery for Difficult Targets
Accelerating Antibody Discovery for Difficult Targets
The Scientist | 1 min read
François Romagné will discuss how RNA immunization and single cell screening enhance antibody generation for poorly immunogenic proteins.
The face of a young woman and the face of an old man surrounded by mechanical clocks.
Daily Gene Expression Rhythms Vary with Sex and Age: Study
Alejandra Manjarrez, PhD | Feb 2, 2023 | 3 min read
By studying tissues from deceased people, a team found that women have more rhythmical gene expression and that this molecular rhythmicity decreases with age.
zebrafish in an aquarium
Epigenetics May Remember Ancestors’ Mutations
Holly Barker, PhD | Dec 1, 2022 | 4 min read
Parents’ mutations, even if they’re not inherited by offspring, could affect subsequent generations through changes to epigenetic marks, a study finds.
 Learn about analyzing mRNA with direct sequence mapping 
Solutions for mRNA Direct Sequence Mapping
Thermo Fisher Scientific | 1 min read
As mRNA therapeutics gain popularity, a novel solution for their development emerges.
illustration of human oocyte
Mammalian Oocytes Store mRNA in Newly Found Membraneless Structure
Alejandra Manjarrez, PhD | Oct 20, 2022 | 3 min read
The findings answer the longstanding question of where these cells hold the mRNA needed to cope with the transcriptional halt preceding meiosis.
A photograph of Christine Guthrie and Hiten Madhani
RNA Pioneer Christine Guthrie Dies at 77
Amanda Heidt | Sep 1, 2022 | 5 min read
Guthrie established foundational concepts in the field of pre-mRNA splicing during her career at the University of California, San Francisco.
3d render illustration of Single strand ribonucleic acid.
Message in a Bottle: Developing mRNA Therapeutics
The Scientist and Mirus Bio | 3 min read
A high efficiency, low toxicity method for direct RNA delivery into cells.
COVID-19 vaccine vials
COVID-19 Vaccines Induce Better Long-Term Immunity than Infection
Jennifer Zieba, PhD | Aug 8, 2022 | 3 min read
For the first time, researchers performed a head-to head longitudinal study comparing the immune response elicited by mRNA and traditional COVID-19 vaccines to primary infections.
3D rendering of a scanning electron micrograph of pink malignant cancer cells against a black background
Cancers Ramp Up Overall mRNA Expression as They Progress
Dan Robitzski | Jun 14, 2022 | 4 min read
A technique for quantifying tumor mRNA production from messy tissue sample data uncovers an unexpected correlation between it and disease stage in 15 cancer types.
The Scientist Speaks - Thieves on the Inside: Viral Control of Host Gene Expression
Niki Spahich, PhD | 1 min read
Britt Glaunsinger discusses how viruses steal from their hosts to take over cellular processes and promote their own survival.
illustration of a large purple molecular complex with a strand of orange RNA running through it and red strand emerging from it
Study Reveals Outsize Role of mRNA Region in Tuning Expression
Sophie Fessl, PhD | Jan 27, 2022 | 3 min read
A new method helps researchers uncover the rules of ribosome recruitment in yeast.
knitted pink heart with a mended hole
CAR T Cells Mend Broken Mouse Hearts
Sophie Fessl, PhD | Jan 6, 2022 | 4 min read
Specialized immune cells generated in vivo reduce cardiac scar tissue in mice, a new study shows.
Isolated Realistic Coronavirus Covid-19 Molecule in a Biological Environment stock photo
Tweak to N Protein Makes Delta Variant More Infectious
Chloe Tenn | Nov 5, 2021 | 2 min read
Using a novel lab technique, researchers identified a mutation that allows the virus to insert more genetic material into host cells.
cartoon image showing colorful collection of syringes, coronavirus particles, and mrna to represent the vaccine development
Optogenetics and mRNA Vaccines Net Lasker Awards
Annie Melchor | Sep 24, 2021 | 2 min read
This year’s winners are Dieter Oesterhelt, Peter Hegemann, Karl Deisseroth, Drew Weissman, Katalin Karikó, and David Baltimore.
Woman holding a CDC COVID-19 vaccination card with both hands.
COVID-19 mRNA Vaccines Appear Effective Against Multiple Variants
Lisa Winter | May 6, 2021 | 2 min read
Data from three studies indicate that fully vaccinated patients are able to stave off severe disease from the B.1.1.7, B.1.351, and P.1 variants.
pregnancy pregnant covid-19 coronavirus pandemic sars-cov-2 vaccine immunization moderna mrna pfizer/biontech
COVID-19 Vaccines Appear Safe During Pregnancy: Early Data
Christie Wilcox, PhD | Apr 22, 2021 | 2 min read
Scientists at the US CDC report no red flags in a preliminary analysis of the safety of Pfizer/BioNTech’s and Moderna’s mRNA-based immunizations among expectant mothers.
Scientists Reverse Engineer mRNA Sequence of Moderna Vaccine
Lisa Winter | Apr 6, 2021 | 2 min read
Stanford University researchers determined the code from spare drops in discarded vials of the COVID-19 vaccine and published it on GitHub.
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