mouse study

An engineered methylation pattern persisted for four generations of mice, demonstrating transgenerational epigenetic inheritance can occur in mammals.

The “on demand” drug immobilizes sperm rather than limit their production, preventing 100 percent of pregnancies in an experiment.

Fast twitch fibers like these could one day be used to treat diseases like Parkinson’s.

A study finds that T cells induced by heroin cross the blood-brain barrier to wreak havoc on the brain, hinting at new ways to prevent withdrawal.

The oil’s omega-3 fatty acids accumulate in the mice’s skin, triggering an immune response that causes hair loss.

Two studies in mice now show that researchers can control when and where CAR T cells are active, potentially overcoming previous hurdles for CAR T–based treatments.

A neural pathway between the gut and the brain led to the release of dopamine when the mice ran on a wheel or treadmill, but only in the presence of a robust microbiome. 

The HIV protein Nef can cause long-term genetic changes that lead to hyperreactive immune cells, according to research in human cells and mice. 

It’s not clear why grain-fed mice are better able to recover after infection, but a study’s findings suggest food type may skew the results of animal studies.

A high-fat diet induced changes to the animals’ vaginal microbiomes that boosted survival after exposure to the virus.

The discovery could one day lead to the development of better antinausea medications.

Mice that received the stem cell–derived treatment were less frail compared with controls, a study reports.

A previously undetected pathway in the mouse brain bypasses the visual cortex to directly activate contagious itch.

The findings will likely help elucidate the effects of chromosome fusions, which can cause disease but have also contributed to evolution.

Using stem cells and a bioreactor, researchers generated living embryos that survived for more than a week and began to develop internal organs.

Nanoparticle-coated bacteria can capture tumor antigens and deliver them to immune cells, triggering a response that improved survival rates in mice.

Nanoparticle-coated bacteria carry cancer-derived proteins to dendritic cells, enabling the immune system to launch a response in a mouse model.

Nearly all mouse sperm have hooks on their heads. But new research suggests the structures slow them down—so what exactly is their purpose?

A new technique reveals cells’ precise locations and functions in the brain. Its developers have already used it to identify a previously unknown neuron type.