metastasis

An immune-inhibiting protein that regulates autophagy halts breast cancers from venturing across tissue borders.

A key gene that fuels the molecular cascade driving prostate cancer bone metastasis progression may open avenues for targeted therapies.

Researchers inhibited molecules that regulate both tumor and immune cell migration and their crosstalk signaling to impede metastasis.

Researchers created a model that uses clinical testing data to locate the primary site of cancer cells with no known origin, likely improving survival.

Using a mouse model of breast cancer brain metastasis, researchers showed that tumor cells require fatty acid synthesis to grow, which offers a potential therapeutic target.

A particular leucine-ferrying tRNA is more abundant in cancerous cells than healthy ones, and lowering its levels inhibits cancer growth, a study finds.

This year, cancer researchers uncovered a variety of ways that tumors can survive and spread, ranging from damaging their own DNA to exploiting the nearby microenvironment for nutrients.

Viscous solutions accelerate the migration of tumor cells and may enable metastasis, according to a new study.

Researchers have long observed a connection between bone metastasis and remodeling, which might be due to a close connection between the two cell types. 

Islands of rigid cells within a matrix of soft ones allow tumors to be both solid and fluid, granting them toughness without losing the ability to break apart.

Scientists discover tumor-associated T cells that drive breast cancer metastasis to lymph nodes.

Head and neck cancer cells lacking the peptide involved in energy production were less likely to metastasize in mice.

More cancer cells are shed from primary tumors when individuals are asleep than when they’re awake, according to observations in mouse models and a small cohort of breast cancer patients.

In vitro and mouse experiments show how cancer cells forced through tiny pores—mimicking the physical experience of metastasis—resisted programmed cell death and avoided detection by the immune cells that would normally kill them.