The third generation of glutamate sensors, iGluSnFR3, tracks glutamate release at the synapse level.1 Upon binding to glutamate, the reporter changes its conformation, intensifying the signal of its fluorescent protein.

          Illustration showing how iGluSnFR3, tracks glutamate release at the synapse level. Upon binding to glutamate, the reporter changes its conformation, intensifying the signal of its fluorescent protein.
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  1. Aggarwal A, et al. Glutamate indicators with improved activation kinetics and localization for imaging synaptic transmission. Nat Methods. 2023;20(6):925-934. 

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