inflammasomes

Bats stay healthy while hosting some of the world’s deadliest viruses. Scientists are just beginning to understand how.

In stressful conditions, specialized protein complexes in microglia induce neurotoxic activity in astrocytes that leads to the change in behavior.

Researchers identify a sensor that sets off inflammation in the absence of infection when it detects RNA from the mobile genetic elements.

A new study suggests that DNA synthesized in the cell cytoplasm drives retinal cell death in an advanced form of age-related macular degeneration, a leading cause of blindness.

Many major biopharmaceutical companies are developing or acquiring drugs that target the NLRP3 inflammasome, a large intracellular complex that researchers say can spark inflammation and stoke diseases of lifestyle and aging.

Drugs targeting patients’ immune systems, rather than the virus itself, could be key to recovery from severe cases of the disease, some researchers suggest.

M proteins from Streptococcus bacteria selectively kill mouse macrophages and human macrophage-like cells by prompting cell death.

ASC specks—protein aggregations that drive inflammation—are released from dying immune cells, expanding the reach of a defense response.

A snapshot of the most highly ranked articles in microbiology and related areas, from Faculty of 1000