human embryonic stem cells

Recent advances in modeling the human placenta, the least understood organ, may inform placental disorders like preeclampsia.

Researchers who work with materials such as fetal tissue and human embryonic stem cells are facing new restrictions, the latest in a long line of regulations, that could impede important advances.

Removal of the 14-day limit for culturing human embryos is one of the main changes in the revised recommendations from the International Society for Stem Cell Research.

Two new papers describe the generation of so-called blastoids, which could avoid the use of embryonic cells and make studying early human development much more accessible.

The latest restrictions require scientists to submit more comprehensive grant applications, and those applications will go through more stringent ethics reviews.

Insulin-producing cells grown in the lab could offer a functional cure for the disease.

Human embryonic stem cells differentiate and organize themselves on a chip.

The research may necessitate the formation of new ethical guidelines.

The finding confirms that a cluster of cells that directs the fate of other cells in the developing embryo is evolutionarily conserved across the animal kingdom.

For the first time, a transplant of replacement tissue grown from stem cells has been shown to be feasible for patients with macular degeneration.

OCT4 is necessary for blastocyst formation in the human embryo, researchers report.

A screen of human embryonic stem cell lines finds several that accumulated changes in the gene TP53, including aberrations commonly seen in cancer.

The UK Stem Cell Bank offers several lines derived from human embryonic tissue.

Scientists issue a call to reconsider the rules governing the creation of tissues, organs, and other structures made possible by recent advances in synthetic biology. 

Removing a specific miRNA from stem cells may induce the expression of endogenous retroviruses that enable the cells to form extra-embryonic lineages.

Since their introduction to the lab, pluripotent stem cells have gone from research tool to therapeutic, but the journey has been rocky.

Since The Scientist published its first issue in October 1986, life-science research has transformed from a manual and often tedious task to a high-tech, largely automated process of unprecedented efficiency.

Tips on how to surmount the challenges of working with CRISPR to manipulate genes in human stems cells to study their function in specific diseases or to correct genetic defects in patient cells.

Pronuclear transfer can reduce the risk of transferring defective mitochondria, a study shows.