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Green bacteria on a blue background.
Mutations Wire Salmonella to Last
Genetic changes attenuated Salmonella’s virulence, potentially enabling the bacteria to cause chronic infections in humans.
Mutations Wire Salmonella to Last
Mutations Wire Salmonella to Last

Genetic changes attenuated Salmonella’s virulence, potentially enabling the bacteria to cause chronic infections in humans.

Genetic changes attenuated Salmonella’s virulence, potentially enabling the bacteria to cause chronic infections in humans.

genetics & genomics

Image of three chromosomes "trees" with the highlighted section displaying telomeres shortening over time as “falling leaves”.
Chromosome Ends in Double Jeopardy
Laura Tran, PhD | May 16, 2024 | 4 min read
Researchers have finally uncovered the other half of the end-replication problem at the lagging strand.
Cartoon of scientist deciding whether to go down the path of well-studied genes or that of the neglected genes. 
Stepping Into the Unknome
Danielle Gerhard, PhD | Mar 8, 2024 | 5 min read
A database of neglected genes may help unlock the mysteries hiding in the overlooked regions of the proteome.
Discover Targeted DNA Sequencing
Targeted DNA Sequencing: Probing for Answers
The Scientist and Roche | 1 min read
A more focused investigation for more in-depth answers.
close-up of X chromosomes
Probing “Selfish” Centromeres Unveils an Evolutionary Arms Race
Michael Lampson, PhD | Apr 3, 2023 | 10 min read
A more complete understanding of nonrandom segregation will shed light on how speciation occurs.
Infographic depicting one way centromeres can "cheat" during meiosis
Infographic: How “Selfish” Centromeres Alter Inheritance
Michael Lampson, PhD | Apr 3, 2023 | 2 min read
Research on so-called selfish genetic loci is providing scientists with greater insight into the biology of chromosome segregation and inheritance.
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Present Your Paper in The Scientist’s Journal Club
The Scientist Staff | 1 min read
Apply today to share your cutting-edge research in The Scientist’s Journal Club.
Artistic rendition of droplet DNA amplification
Finally, Scientists Sequence Single Cells with Long-Read Technology
Holly Barker, PhD | Mar 8, 2023 | 4 min read
By combining two innovative approaches, researchers can now sequence the full spectrum of mutational differences between individual cells’ genomes.
Michael Green smiling at the camera in front of a shelf in the lab
Molecular Biologist Michael Green Dies at 69
Lisa Winter | Mar 7, 2023 | 2 min read
Beyond his achievements in academia, he also cofounded three pharmaceutical companies and filed 15 patents related to cancer therapeutics. 
A magnifying glass examining a double-helix DNA strand.
Targeted Next-Generation Sequencing with myBaits
Arbor Biosciences | 1 min read
Hybridization-based capture can provide target enrichment for more powerful next-generation sequencing.
Learn How Researchers Make the Most of Viral Vectors for Gene Therapy
Viral Vector Platforms for Gene Therapy
The Scientist | Feb 9, 2023 | 1 min read
In both the laboratory and clinic, scientists harness viral genetic transfer capabilities to develop gene therapies that modulate cellular function.
Illustration of DNA double helix with purple background.
Unbalanced Allele Expression Associated with Mutation, Disease
Natalia Mesa, PhD | Feb 2, 2023 | 5 min read
A study identifies nearly 3,000 genes where one allele tends to be expressed more than the other, but the findings ignited controversy in the field. 
Learn how to design an efficient custom CRISPR screen
Designing CRISPR Screens for Efficient Gene Function Analysis
The Scientist and Twist Bioscience | 1 min read
Discover tips and tricks to successfully perform custom CRISPR screens.
A California Chinook Salmon Jumps into a waterfall during spawning season
Geneticists Light Up Debate on Salmon Conservation
Christie Wilcox, PhD | Feb 1, 2023 | 10+ min read
Splitting Chinook salmon into two groups based on their DNA could aid conservation efforts. But some researchers argue that this would be a misuse of the data.
Infographic comparing the fall and spring salmon runs
Infographic: An Incredible Journey
Christie Wilcox, PhD | Feb 1, 2023 | 1 min read
Chinook make their way up the Klamath River every year, but fewer and fewer arrive in the spring.
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Improving Reproducibility with Automated Liquid Handling
The Scientist Creative Services Team in collaboration with Eppendorf | 2 min read
Automated liquid handling reduces manual labor and improves precision, reproducibility, and throughput.
Timeline summarizing a series of petitions filed about the Chinook salmon
Timeline: An Extended Battle
Christie Wilcox, PhD | Feb 1, 2023 | 3 min read
Various concerned groups have been petitioning NOAA Fisheries to list spring-run Chinook salmon in Oregon and Northern California for over a decade.
A pair of prairie voles (Microtus ochrogaster)
Monogamous Rodents Don’t Need “Love Molecule” To Pair Up
Natalia Mesa, PhD | Jan 27, 2023 | 4 min read
Prairie voles lacking functional receptors for oxytocin form normal social bonds, a finding that could explain the hormone’s clinical failures.
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September 22, 2021 - Winning Westerns Technique Talk: Perfecting Western Blotting
The Scientist Creative Services Team in collaboration with Merck | 1 min read
Learn tips and tricks for optimizing Western blot experiments in this workshop.
composite of images from favorite posts
Our Favorite Genetics Stories of 2022
Christie Wilcox, PhD | Dec 22, 2022 | 4 min read
This year’s stories highlight the expanding versatility of genetic techniques and the increasing utility of such research in all life science fields.
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