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Image of a stem cell and DNA against a light background.
Using Genetic Cartography to Map Cell Lineage
By coupling cell lineage tracking with molecular gene expression patterns, researchers deciphered how gene activity influences immune cell production.
Using Genetic Cartography to Map Cell Lineage
Using Genetic Cartography to Map Cell Lineage

By coupling cell lineage tracking with molecular gene expression patterns, researchers deciphered how gene activity influences immune cell production.

By coupling cell lineage tracking with molecular gene expression patterns, researchers deciphered how gene activity influences immune cell production.

gene expression

Two drawn heads on a blue background with gears in their heads. A red spot on two gears is magnified over one head.
Biological Sex Influences Brain Protein Expression
Shelby Bradford, PhD | Apr 4, 2024 | 3 min read
Neurological disorders often have sex biases, and these differences could be due to altered protein expression in the brain.
Novelty Activates a Long Noncoding RNA for Spatial Learning in Mice
Shelby Bradford, PhD | Feb 6, 2024 | 4 min read
Genes activated in new environments include those used during development.
Researchers can obtain epigenetic information in addition to genetic insights from a single DNA sample.
The Six-Base Genome Reveals Multimodal Data from a Single DNA Sample
The Scientist and biomodal | 4 min read
To gather multiomic insights, researchers used to combine data from multiple workflows, but duet evoC provides more information from less sample in one workflow.
Plant (<em >Arabidopsis thaliana</em>) root tips analyzed with PHYTOMap.
Illuminating the Plant Gene Map
Laura Tran, PhD | Nov 2, 2023 | 4 min read
PHYTOMap revealed the intricate genetic plant landscape, which helped researchers better understand how cells and gene expression influence each other in three-dimensional space.
Professor Alexandra Whiteley and graduate student Autumn Matthews look at an image of a western blot on their laboratory computer.
An Ancient Viral Protein May Play a Key Role in ALS
Aditi Subramaniam, PhD | Aug 15, 2023 | 4 min read
Researchers find that UBQLN2 gene dysfunction causes a virus-like protein to accumulate in cells, which changes gene expression and may contribute to disease progression in amyotrophic lateral sclerosis (ALS).
A scientist loads a 96-well plate containing qPCR reactions into a thermal cycler for DNA amplification and detection.
Insights into qPCR: Protocol, Detection Methods, and Analysis
Tanuka Biswas, PhD | 6 min read
Learn about quantitative PCR (qPCR), including its fundamentals, common applications, modes of detection, and key quantification methods.
Tumor microenvironment concept with cancer cells
Cancers Protect Themselves Against Their Own Mutations
Ida Emilie Steinmark, PhD | Aug 1, 2023 | 2 min read
Tumors overexpress certain genes to survive a growing pile of harmful mutations, a trait that scientists could exploit to target with drugs.
Composition of DNA with a glitch effect
“Silent” Mutations Make Noise In Cancer
Katarina Zimmer | May 1, 2023 | 10+ min read
Synonymous mutations have long been ignored in cancer studies since they don’t affect the amino acid sequences of proteins. But research increasingly reveals that they can have disease-driving effects.
Sartorius
Understanding the Blood Cancer Genomic Landscape 
The Scientist | 1 min read
Information about the genomic and immunological characteristics of blood cancers is helping scientists discover and develop new immunotherapies.
Histology showing IL-6 expression
Immune Molecule Alters Cellular Makeup of Human Brain Organoids
Charles Q. Choi, Spectrum | Apr 17, 2023 | 4 min read
The changes may help explain the link between maternal infection and autism, though more research is needed.
Artist&rsquo;s rendition of orange DNA coiled around a blue histone protein.
“Cryptic Transcription”: How Aging Cells Express Fragments of Genes
Kamal Nahas, PhD | Apr 6, 2023 | 4 min read
Aging cells with weakened gene regulation spuriously transcribe RNAs, but their impact on health and longevity still needs to be examined.
VAI
One Sequence, Many Variations
Van Andel Institute | 5 min read
Andrew Pospisilik explores the epigenetic changes that give organisms the plasticity to change in response to their environments.
Headshots of three people smiling and looking at camera.
2023 Brain Prize Awarded for Research on Synaptic Plasticity
Natalia Mesa, PhD | Mar 23, 2023 | 3 min read
The Lundbeck Foundation announces an international cohort of neuroscientists have collectively won the €1.3 million Brain Prize.
The face of a young woman and the face of an old man surrounded by mechanical clocks.
Daily Gene Expression Rhythms Vary with Sex and Age: Study
Alejandra Manjarrez, PhD | Feb 2, 2023 | 3 min read
By studying tissues from deceased people, a team found that women have more rhythmical gene expression and that this molecular rhythmicity decreases with age.
VAI
Exposed: Environmental Echoes in Health - A Special Podcast Series
The Scientist and Van Andel Institute | 2 min read
Epigenetic experts discuss how environment and diet leave lasting impressions on the human genome.
Illustration of DNA double helix with purple background.
Unbalanced Allele Expression Associated with Mutation, Disease
Natalia Mesa, PhD | Feb 2, 2023 | 5 min read
A study identifies nearly 3,000 genes where one allele tends to be expressed more than the other, but the findings ignited controversy in the field. 
Coronal section of a brain
Immunity-Linked Genes Expressed Differently in Brains of Autistic People
Laura Dattaro, Spectrum | Jan 11, 2023 | 4 min read
Data from postmortem brain tissues adds to the evidence that inflammation is associated with autism.
Discover how to Select and Design qPCR Probes
Selecting Probes That Rise to Any qPCR Challenge
The Scientist and LGC Biosearch Technologies | 1 min read
Learn how to select qPCR probes that match downstream applications.
2022 Top 10 Innovations&nbsp;
2022 Top 10 Innovations
The Scientist | Dec 12, 2022 | 10+ min read
This year’s crop of winning products features many with a clinical focus and others that represent significant advances in sequencing, single-cell analysis, and more.
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