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A chromosome is gradually unwinding until the DNA double helix is visible. Proteins interact with parts of the DNA. Antibodies are attached to these protein-DNA interacting regions.
Chromatin Immunoprecipitation Reveals DNA-Protein Interactions
Proteins interact with DNA to regulate many vital processes in cells. Nearly 40 years ago, researchers developed a way to map these molecular connections.
Chromatin Immunoprecipitation Reveals DNA-Protein Interactions
Chromatin Immunoprecipitation Reveals DNA-Protein Interactions

Proteins interact with DNA to regulate many vital processes in cells. Nearly 40 years ago, researchers developed a way to map these molecular connections.

Proteins interact with DNA to regulate many vital processes in cells. Nearly 40 years ago, researchers developed a way to map these molecular connections.

Foundations

The image shows six different panels containing cells. On each panel, the cells are labelled using a different fluorescent dye that highlights features of a specific organelle within the cells.
Cell Painting: Exploring the Richness of Biological Images
Mariella Bodemeier Loayza Careaga, PhD | Sep 8, 2023 | 4 min read
By coloring different organelles simultaneously, cell painting allows scientists to pick up subtle changes in cell function in response to drugs and other perturbations.
Image showing recombinant DNA
A Sticky Situation: Recombinant DNA Technology
Kathryn Loydall, PhD | May 1, 2023 | 5 min read
Janet Mertz’s work with simian virus 40 DNA during her graduate years was pivotal for developing DNA recombination as we now know it.
X-ray crystallography of penicillin
Crystal-Clear Penicillin, 1945
Brittany McWilliams | Apr 3, 2023 | 4 min read
Political activist and Nobel winner Dorothy Crowfoot Hodgkin pioneered X-ray crystallography to discover the molecular structures of penicillin and insulin.
In urban bathhouses in Germany and the surrounding low countries, bathhouse proprietors, known as baders, provided visitors with basic medical care. To draw blood, baders would scratch the skin before placing a heated cupping glass over the incision to extract blood and purge the body. Other tools associated with baders, including dental forceps and an amputation saw, hint at further services they provided.
Bathing Through the Ages: 1300–1848
Clare Watson | Mar 1, 2023 | 2 min read
Public bathing, ubiquitous around the world and through the ages, plays an often-unappreciated role in public health.
Glass blown and sculpted model of the golden bellapple (<em>Passiflora laurifolia</em>)
Glass Menagerie, 1863–1936
Dan Robitzski | Feb 1, 2023 | 3 min read
The father-and-son duo Leopold and Rudolf Blaschka crafted thousands of scientifically accurate models of plants and sea creatures as teaching aids. 
Glass-blown and sculpted model of the sea anemone (<em>Phymactis florida</em>)
Slideshow: The Lifelike Glass Models of Leopold and Rudolf Blaschka
Dan Robitzski | Feb 1, 2023 | 3 min read
The father-and-son duo, the last generations of a long line of renowned glassworkers, crafted thousands of realistic models of plants and sea creatures.
A building behind trees
Ford Foundation Sunsets Diversity Fellowships
Andy Carstens | Sep 27, 2022 | 6 min read
For more than 50 years, the program has served as a pipeline to get more scholars of color into academic institutions.
A photo of soybean pods
The Right Chemistry, 1935
Catherine Offord | Mar 1, 2022 | 3 min read
Percy Lavon Julian, a young, Black scientist working in Jim Crow America, gained international recognition after beating chemists at the University of Oxford in the race to synthesize the alkaloid physostigmine, used for decades as a treatment for glaucoma.
A lithograph of a woman sitting up in bed while a nurse attends to her.
Death by Nostalgia, 1688
Lisa Winter | Feb 1, 2022 | 3 min read
Before its association with a pining for the toys or TV shows of yesteryear, nostalgia was deemed a dangerous psychiatric disorder.
Formed of various flowers, this personification cartoon of a female botanist, painted by George Spratt, was pasted into Allen’s copy of The English Flora.
La Botaniste, 1810–1865
Sukanya Charuchandra | Jan 4, 2022 | 2 min read
Elaborate annotations hidden in a copy of Sir James Edward Smith’s The English Flora hinted at the life of a mysterious woman botanist.
In one of the only known photos of Abraham Lincoln taken on the day of the Gettysburg Address, Lincoln can be seen seated, hatless, just below and to the right of the flag. Lincoln began developing symptoms of smallpox on the train home to Washington, DC.
Presidential Pox, 1863
Annie Melchor | Dec 1, 2021 | 3 min read
Researchers continue to debate whether US President Abraham Lincoln was coming down with smallpox as he delivered his famous Gettysburg Address, and if he had been immunized.
Photograph of drought land due to climate change
An Earthy-Smelling Substance, 1964
Lisa Winter | Nov 1, 2021 | 3 min read
How the pungent odor that occurs after a light rain became a well-studied phenomenon
Photograph of a waterfall
Falling Water, Rising Rocks, 1834
Catherine Offord | Oct 1, 2021 | 2 min read
Intrigued by an optical illusion he experienced while traveling in Scotland, Robert Addams wrote what is now considered one of the definitive observational accounts of so-called motion aftereffects.
A black and white photo of two sets of flowers in test tubes, one of which is wilting
Posies, Poison, and Periods, Early 1920s
Annie Melchor | Sep 1, 2021 | 3 min read
Centuries of folklore backed by scientists in the early 1900s have perpetuated the idea that menstruating women can exert dangerous forces.
Birth of Midwifery, Circa 100 CE
Lisa Winter | Aug 1, 2021 | 3 min read
Soranus of Ephesus’s manual shaped the way midwifery was practiced for more than a millennium.
two black-and-white microscope images, one with a few black dots, the other with many rod-shaped bacteria
Identifying a Killer, 1895
Catherine Offord | Jul 1, 2021 | 4 min read
A contaminated ham put bacteriologist Émile Pierre-Marie van Ermengem on the path to discovering the microbe that produces botulinum toxin.
Stamping Out Science, 1948
Catherine Offord | May 1, 2021 | 4 min read
Trofim Lysenko’s attacks on geneticists had long-term effects on Russian science and scientists, despite a lack of evidence to support his beliefs about biological inheritance.
Bile and Potatoes, 1921
Jef Akst | Apr 1, 2021 | 3 min read
One hundred years after its invention, BCG has stood the test of time as a vaccine against tuberculosis.
Identity Crisis, 1906
Catherine Offord | Mar 1, 2021 | 4 min read
A famous account of multiple personality disorder in the early 20th century foreshadowed a century of controversial diagnoses and debate among psychiatrists.
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