ADVERTISEMENT
3D illustration of a DNA molecule with sparkling effects.
A Prime-Editing Based Approach Records Cellular Genetic History
Researchers developed a technique, ENGRAM, to keep a running log of the elements that control gene expression in cells. 
A Prime-Editing Based Approach Records Cellular Genetic History
A Prime-Editing Based Approach Records Cellular Genetic History

Researchers developed a technique, ENGRAM, to keep a running log of the elements that control gene expression in cells. 

Researchers developed a technique, ENGRAM, to keep a running log of the elements that control gene expression in cells. 

  1. Home
  2. Subjects
  3. CRISPR

CRISPR

Two scientists at a table with two petri dishes of mold. One scientist opens a cloche revealing a meat-like patty made of koji mold.
Mold Burger: Coming Right Up
Laura Tran, PhD | Aug 15, 2024 | 2 min read
From the laboratory to the table, researchers cooked bioengineered fungi into a tempting patty.
Dark blue RNA strands with a light blue background.
A CRISPR Tool for Tinkering with the Human Transcriptome
Danielle Gerhard, PhD | Jul 23, 2024 | 5 min read
Human cells repair RNA breaks induced by a programmable CRISPR system, paving the way for temporary treatments for genetic diseases.
Optimizing Gene Editing Experimental Design
Optimizing Gene Editing Experimental Design
The Scientist Staff | 1 min read
In this webinar, Jacob Lamberth will discuss the critical variables and strategies for revolutionizing gene editing experiments.
A tick on a leaf.  
How the Crimean Congo Virus Sneaks into Cells
Maggie Chen | Jul 15, 2024 | 4 min read
A tickborne virus uses cholesterol receptors to worm its way into the cell.
A big tree in a forest
The Immeasurable Impact of a Scientist
Meenakshi Prabhune, PhD | Jul 15, 2024 | 2 min read
A scientist's true legacy lies in the countless researchers they inspire rather than their citation metrics.
Optimizing Gene Editing Experimental Design
Optimizing Gene Editing Experimental Design
The Scientist Staff | 1 min read
In this webinar, Jacob Lamberth will discuss the critical variables and strategies for revolutionizing gene editing experiments.
mRNA molecule is manufactured from a ribosome. 
A Twisted Secret that Extends mRNA Longevity in Cells
Maggie Chen | Jun 28, 2024 | 3 min read
By tinkering with branched mRNA structures, scientists lay the groundwork to build better vaccines in the future. 
A digital graphic rendering of multiple DNA double helices on a white background.
Targeted Gene Integration for High-Throughput Applications
Nathan Ni, PhD | Jun 20, 2024 | 4 min read
A new approach using two types of recombinases lets scientists insert larger DNA payloads into human pluripotent stem cells faster than ever before. 
Bringing Gene Therapy to the Brain
Bringing Gene Therapy to the Brain
The Scientist Staff | 1 min read
In this webinar, Douglas Marchuk and Viviana Gradinaru will discuss how scientists can overcome physiological barriers preventing gene therapies from reaching the brain. 
Image of Alison Van Eenennaam holding a black calf in her arms as they pose for the camera.
Herding Innovation in Livestock
Laura Tran, PhD | Jun 14, 2024 | 9 min read
Alison Van Eenennaam uses genome-editing technologies to aid beef cattle production and animal welfare.
3D cubes showing letters representing the four DNA bases (adenine, guanine, cytosine, and thymine) and small DNA helices.
Discovering the Functions of Noncoding Sequence Variants
Niki Spahich, PhD | Jun 12, 2024 | 4 min read
Neville Sanjana explored noncoding genomic regions by combining pooled CRISPR screening and single cell sequencing.
Molecular illustration of CRISPR editing the DNA double helix
Prime Time Precision with CRISPR Technologies
The Scientist | 1 min read
Base editors and prime editors help researchers perform more precise in vivo and ex vivo translational research.
Two cells fluorescently stained for normal (red) and damaged (green) lysosomes.
Cancer Cells Spread When They Stop Recycling Waste
Kamal Nahas, PhD | May 8, 2024 | 4 min read
An immune-inhibiting protein that regulates autophagy halts breast cancers from venturing across tissue borders.
Close-up painting of hands drawing the DNA helix.
Measuring Mutagenesis with Precision Genome Editing
Deanna MacNeil, PhD | May 3, 2024 | 5 min read
A new prime editing sensor library targeting p53 mutations allowed scientists to interrogate thousands of tumor genotypes as they arose in endogenous contexts.
An illustration of multicolored DNA bands on a gel after Sanger sequencing.
The Sequencing Revolution
The Scientist | 1 min read
Learn how cutting-edge sequencing techniques accelerate basic and disease research.
3D rendered RNA strand
MEGA CRISPR: Engineering Better Immunotherapies with RNA Editing
Deanna MacNeil, PhD | Apr 1, 2024 | 3 min read
Multi-targeted Cas13 screens help researchers avoid permanent DNA cuts and evade T cell exhaustion.
B cells secreting antibodies that target virus particles.
Stem Cell Editing Repairs Severe Immunodeficiency
Kamal Nahas, PhD | Mar 20, 2024 | 5 min read
Scientists hoping to treat immunodeficiencies using gene therapy have found a way to edit stem cells in mice without disrupting gene regulation.
iStock
Epigenetics in a Dish
The Scientist | 2 min read
Jonathan Weissman and Luke Gilbert share how they developed several CRISPR-based epigenetic editors and how these tools differ from traditional CRISPR.
bacteria and DNA molecules on a purple background.
Engineering the Microbiome: CRISPR Leads the Way
Mariella Bodemeier Loayza Careaga, PhD | Mar 15, 2024 | 10+ min read
Scientists have genetically modified isolated microbes for decades. Now, using CRISPR, they intend to target entire microbiomes.
ADVERTISEMENT
ADVERTISEMENT