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Cuboidal DNA origami block containing parallel double helices (gray columns) decorated with tumor antigens (green proteins) and CpG adjuvants (yellow helices) on opposing faces.
Fighting Tumors with DNA Origami
Researchers bolster antitumor immune defenses using cancer vaccines made from DNA origami.
Fighting Tumors with DNA Origami
Fighting Tumors with DNA Origami

Researchers bolster antitumor immune defenses using cancer vaccines made from DNA origami.

Researchers bolster antitumor immune defenses using cancer vaccines made from DNA origami.

cancer vaccine

TK
Infographic: Vaccinating Against Tumors
Shelby Bradford, PhD | Mar 15, 2024 | 1 min read
Cancer vaccines offer the opportunity to use the patient’s own immune system in the fight against tumors.
A needle drawing up fluid from an unlabeled vial.
Cancer Vaccination as a Promising New Treatment Against Tumors
Shelby Bradford, PhD | Mar 15, 2024 | 10+ min read
Vaccination has beaten back infections for more than a century. Now, it may be the next big step in battling cancer.
A Brief History of Stem Cells
Scientific Breakthroughs with Stem Cells
Nele Haelterman, PhD | 1 min read
Discover the various ways scientists bolster stem cells to understand and cure disease.
A syringe delivering a fleet of DNA nanorobots to a cancer cell.
Building Biomolecular Machines
Danielle Gerhard, PhD | Jan 1, 2024 | 2 min read
William Shih draws inspiration from origami and jigsaw puzzles in his quest to build bigger DNA nanorobots.
Salmonella (pink) invading a human epithelial cell (yellow)
Modified Salmonella Revs Immune Response, Combats Tumors in Mice
Natalia Mesa, PhD | Feb 3, 2022 | 5 min read
When coated with positively charged particles, the bacteria shuttled antigens out of tumors and activated the immune system, a study finds.
personalized vaccines
Infographic: Neoantigen Prediction for Personalized Vaccine Design
Jasreet Hundal and Elaine R. Mardis | Jul 15, 2019 | 3 min read
See how a computational pipeline uses next-generation sequencing data to identify genetic alterations that produce cancer-specific antigens.
custom targeted cancer vaccine
Personalized Cancer Vaccines in Clinical Trials
Jasreet Hundal and Elaine R. Mardis | Jul 15, 2019 | 10+ min read
The field is young, but predicting antigens produced by patients’ malignant cells could yield successful treatments for individuals with a range of cancer types.
Table: Personalized Cancer Vaccine Trials in the United States
Jasreet Hundal and Elaine R. Mardis | Jul 15, 2019 | 6 min read
There are currently more than two dozen ongoing Phase 1 and Phase 2 trials using different vaccine platforms such as DNA, RNA, synthetic long peptides, and dendritic cells.
Miriam Merad
Cancer Vaxxer: A Profile of Miriam Merad
Anna Azvolinsky | Apr 1, 2019 | 8 min read
The Mount Sinai oncologist studies innate immune cells with the goal of designing novel immunotherapies, including cancer vaccines.
New Ovarian Cancer Vaccine Shows Promise
Catherine Offord | Apr 12, 2018 | 2 min read
A preliminary clinical trial finds that the personalized therapy improves survival rates and has no severe side-effects.
Stem Cell Vaccine Protects Mice From Cancer
Ruth Williams | Feb 15, 2018 | 3 min read
Stem cells and cancer cells have enough molecular similarities that the former can be used to trigger immunity against the latter.
Locally-Injected Immunotherapy Eradicates Tumors in Mice
Diana Kwon | Feb 1, 2018 | 2 min read
The treatment also curbed the growth of nearby metastases that did not receive the drug.
Personalized Cancer Vaccines Show Promise for Melanoma
Jef Akst | Jul 6, 2017 | 2 min read
In two early trials, vaccines tailored to the mutations in individuals’ cancers appeared to protect 12 of 19 patients against relapse. 
Researchers Call for Retraction of Paper that Questions HPV Vaccine
Jef Akst | Dec 22, 2016 | 2 min read
Oncologists have raised concerns about a mouse study that suggests the vaccine for human papillomavirus could cause brain damage.
Viral Immunotherapy for Melanoma
Kerry Grens | May 28, 2015 | 2 min read
Phase 3 data from a clinical trial show a positive response to a melanoma treatment based on a modified herpesvirus.
Personalized Cancer Vaccines
Anna Azvolinsky | Apr 2, 2015 | 3 min read
A dendritic cell vaccine targeting melanoma patients’ tumor-specific mutations can activate a broad range of cancer-fighting T cells. 
Opinion: Making Cancer Vaccines Work
Abhishek Srivastava and Haval Shirwan | Mar 30, 2015 | 3 min read
Armed with the right adjuvant system, vaccines are poised to tackle one of the world’s most intractable diseases. 
Week in Review: June 23–27
Tracy Vence | Jun 26, 2014 | 3 min read
Tracking chikungunya virus; reconsidering wood decay-based fungal classification; ASC specks spread inflammation; antibiotic tolerance in E. coli; RIKEN review yields corrections
Targeted Brain Cancer Vaccine
Anna Azvolinsky | Jun 25, 2014 | 3 min read
Mouse study demonstrates the ability of a cancer vaccine targeted against a specific oncogenic mutation to elicit a protective anti-tumor immune response. 
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