cancer gene expression

Digging into how and why some genes are resurrected after death sounds morbid, but it has practical applications. 

Synonymous mutations have long been ignored in cancer studies since they don’t affect the amino acid sequences of proteins. But research increasingly reveals that they can have disease-driving effects.

Jumping genes are let loose in cancerous cells, with multiple effects on cell health.

Noncoding RNAs and microproteins, once considered genomic noise, are turning out to be critical to the progression of some types of cancer.

Transposons may be key players in how tumors develop and spread, but they also keep cancer at bay in some circumstances.

The tiny strings of RNA promote translation of a protein implicated in cancer, a hint they could regulate gene expression in more ways than previously thought.

A study finds that XIST, the gene that shuts down one X chromosome in people who have two, is linked to cancer in males. 

Most differences in gene expression among cells within a tumor are likely due to environment or noise, a study suggests. 

Viral remnants make up 8 percent of the human genome, and a new study finds that these sequences are still active in healthy people.

A technique for quantifying tumor mRNA production from messy tissue sample data uncovers an unexpected correlation between it and disease stage in 15 cancer types.

Tumors contain thousands of genetic changes, but only a few are actually cancer-causing. A quicker way to identify these driver mutations could lead to more targeted cancer treatments.

This year revealed just how much scientists have learned about the disease, from how animals become naturally cancer-resistant to how tumor cells harness extracellular DNA to develop rapid drug resistance.

In a retrospective analysis, a team found that an algorithm integrating the gene expression of a tumor with the radiation dose a patient received predicted how well the patient responded to the treatment.

In the last decade, researchers have come to realize that tumors harbor bits of extrachromosomal DNA that can drive malignancy.

Researchers are uncovering how circular bits of DNA found in some cancer cells can help tumors evolve and kill.

The Harvard Medical School researcher’s work on the genetic basis of protein coding and production led him to make groundbreaking discoveries in immunology, molecular biology, and cancer genetics.

In the largest study of its kind to date, researchers find more than 850 rare, heritable genetic alterations that can predispose humans to cancer.

At the University of California, Santa Cruz, the researcher combs the cancer genome, looking for weaknesses.

The tumor biologist’s landmark discovery provided the first clear evidence that genetic mutations could lead to cancer, and gave rise to a crucial cancer drug.