animal models

Not all degenerated intervertebral discs are painful; a new study identified a subset of disc cells that triggers a pathway to pain.

Transgenic ferret models ratted out how a rare cell type affects airway function.

Researchers found new mechanisms and drug targets for cystinosis.

Molecular studies may point to underlying genetics and therapeutic targets.

Jie Sun shares how his curiosity, creativity, and motivation to address clinical public health needs steer his research in immunology and infectious disease.

The effect appears to be mediated by a gut-secreted peptide that signals to neurons in the brain that modulate the response to mechanical vibrations.

The opportunistic pathogen Klebsiella aerogenes degrades estradiol and induces depressive-like behavior in mice, a study finds.

A reference sequence for this emerging model organism will facilitate research on type 2 diabetes and the health effects of circadian rhythm disruption.

It’s not clear why grain-fed mice are better able to recover after infection, but a study’s findings suggest food type may skew the results of animal studies.

The long-tailed macaque and pig-tailed macaque are now endangered in the wild according to the IUCN Red List, which says exports for monkey research are partially to blame.

Experiments in animals and observations in humans suggest that the amount of proline circulating in one’s plasma has a strong association with depression severity.

Mice rendered infertile through ovary cell–targeting mutations gave birth to seemingly normal offspring through natural mating after a virus-based gene therapy was injected into their ovaries.

Researchers find a way to wipe out the brain’s immune cell corps and send in new and improved versions.