adeno-associated virus

Cancer vaccines offer the opportunity to use the patient’s own immune system in the fight against tumors.

Ten years ago, scientists put DNA barcodes in AAV vectors, creating an approach that simplified, expedited, and streamlined AAV screening. 

Take the leap from shake flasks to bioreactors.

An aqueduct connecting the brain to the ear may make gene therapy for hearing loss less invasive.

In both the laboratory and clinic, scientists harness viral genetic transfer capabilities to develop gene therapies that modulate cellular function.

Two independent groups suggest the suite of recent unexplained hepatitis cases may stem from coinfection with an adeno-associated virus and a helper adeno- or herpesvirus, a duo which may be especially virulent in children with a particular genetic variant.

Explore how humanized liver chimeric mouse models smooth the transition between the laboratory and clinical trials.

How to detect impurities during gene therapy vector production

Adeno-associated viral vectors can deliver gene therapies, but AAV-neutralizing antibodies might prevent the medicines from working.

The midwestern state has quietly laid the groundwork for a biotech hub.

Canines treated with an adeno-associated viral (AAV) vector showed evidence that the therapeutic DNA held within the virus can integrate into the host genome, risking the activation of oncogenes.

The US Food and Drug Administration halts a study by Solid Biosciences after a patient experiences severe side effects following treatment.

Preliminary data from Sarepta Therapeutics has exceeded expectations, causing a surge in company stock prices this week.

Biotech stocks fell in response to the news. 

Pancreatic cells engineered to produce insulin did not immediately provoke an immune response.

Researchers deploy ancestors of today’s adeno-associated viruses to deliver gene therapies without immune system interference.