AAV

With the help of directed evolution, scientists inch closer to developing viral vectors that can cross the human blood-brain barrier to deliver gene therapy.

Cancer vaccines offer the opportunity to use the patient’s own immune system in the fight against tumors.

Ten years ago, scientists put DNA barcodes in AAV vectors, creating an approach that simplified, expedited, and streamlined AAV screening. 

Lauren Drouin shares how personal connections and scientific curiosities drive her work on gene therapy viral vectors. 

In the race to deliver successful gene therapies, frontrunner AAVs come head to head with underdog lipid nanoparticles. 

Gene therapy may be the first step toward curing a rare genetic epilepsy.

Researchers find that an increased heart rate can induce anxiety in mice, given the right context.

In both the laboratory and clinic, scientists harness viral genetic transfer capabilities to develop gene therapies that modulate cellular function.

Explore the genetics revolution in medicine.

Two independent groups suggest the suite of recent unexplained hepatitis cases may stem from coinfection with an adeno-associated virus and a helper adeno- or herpesvirus, a duo which may be especially virulent in children with a particular genetic variant.

Mice rendered infertile through ovary cell–targeting mutations gave birth to seemingly normal offspring through natural mating after a virus-based gene therapy was injected into their ovaries.

Explore how humanized liver chimeric mouse models smooth the transition between the laboratory and clinical trials.

How to detect impurities during gene therapy vector production